QuoteThis is really it: While so many are deeply dedicated to advancing science and improving care, most individuals also want to be the one who does it.
Quotethe concern is that this process has resulted in a culture of data hoarding–at the level of individual scientists, individual research groups, individual hospitals, even individual countries (who legislate against health data egress), foreclosing the possibility of benefiting from the deeper insights only possible with larger datasets.
QuoteOne response to a health system that seems unwilling to part with data is for patients to drive this process themselves; let patients request their data, and drive the sharing.
QuoteMost papers are generated for advancement of careers rather than advancement of human knowledge." —Joseph Hyder, professor of anesthesiology, Mayo Clinic
Quote"Science, I had come to learn, is as political, competitive, and fierce a career as you can find, full of the temptation to find easy paths." — Paul Kalanithi, neurosurgeon and writer (1977–2015)
QuoteScientists often learn more from studies that fail. But failed studies can mean career death. So instead, they're incentivized to generate positive results they can publish. And the phrase "publish or perish" hangs over nearly every decision. It's a nagging whisper, like a Jedi's path to the dark side.
Quote from: LinksEtc on April 26, 2016, 06:16:11 PM
"ALL THE YOUNG JEDIS"
http://www.curiumco.com/news-master/2016/1/28/all-the-young-jedisQuote
Luke: Is the dark side stronger?
Yoda: No - quicker, easier, more seductive... like a giving a TED talk.Quotenot including proper controls, omitting data that doesn't fit expectations, letting assumptions go untested
QuoteIt's hard to be generous, when we often have to guard ourselves against those who will be the opposite – taking credit, taking advantage, capitalizing the efforts of others.
QuoteElements of generosity included in the image in this post:
Diversity
Fairness
Collaboration
Service
Openness
Sharing
Giving
QuoteIt's quite difficult to track down patients with intriguing case histories, scattered as they are across the country and protected by blankets of privacy. So instead of going through doctors or hospitals, the project makes its appeal to patients directly.
QuoteIn six months, more than 1,800 patients with metastatic breast cancer have joined, including hundreds of exceptional responders. In return, the project involves them in its decision-making and promises to share its data with any scientist who asks.
QuoteFood Allergy Research & Education (FARE) is proud to announce it has received a Eugene Washington Engagement Award from the Patient-Centered Outcomes Research Institute (PCORI)
QuoteFARE's two-year project, "Empowering Patient Partners and Key Stakeholders to Develop a Patient-Centric Food Allergy Research Program," seeks to address an unmet need in the research field by developing a partnership of patients empowered to work with other key stakeholders.
Quoteit is crucial that the perspectives, preferences and needs of the patient are prioritized
QuoteThe application period to become a member of FARE's Outcomes Research Advisory Board will open today and run for approximately six weeks.
QuoteThere may be an incredibly simple intervention out there that could cost nothing and save lives, but we won't implement it. Doctors will point to it, and argue about it, but it won't go anywhere for a long, long time. There's no money in it. It's not sexy.
QuoteThere's an interesting back-and-forth between doctors in the New England Journal of Medicine and the British Medical Journal on whether conflicts of interest are actually a huge problem in medicine — and whether efforts to regulate them do more harm than good.
QuoteThis discussion has been intense because the stakes are very high. If manipulated research data allow bad drugs to enter the market, people can die. Conversely, if unjustified prejudice against industry slows the progress of research, that could kill people too.
Quotetis but idle-headed worke; quasi-purloining of my owne humble efforts
QuoteScientists are in a real bind when it comes to peer review. It's hard to be objective when we're all among the peer reviewing and peer-reviewed, or plan to be. Still, we should be able to mobilize science's repertoire to solve our problems.
Quote.@Richard56 I disagree with your article on peer review. My response is here: timeshighereducation.co.uk/content/the-pe... @trished @tessajlrichards @bmj_latest
QuotePerhaps Trish might be able to design some better studies to investigate the value or otherwise of peer review.
QuoteWhat's worse? Worrying about COI, or worrying about worrying about it? @afrakt insightful meta-thoughts on meta-data twitter.com/afrakt/status/...
QuoteBut for the data that we are interested in, we need to know the appropriate methods for thinking about and analyzing them. And by "we", I mean pretty much everyone.
Quotepublication bias has public health consequences; this case would be good to include in med/resident/fellow education twitter.com/bengoldacre/st...---
QuotePhysicians' enthusiasm for prescribing imiquimod to treat children with molluscum contagiosum would likely dramatically decrease if they knew about the 2 RCTs.
QuoteIn recent decades, the access to information has gotten easier.
Quotenow our challenge is sifting through the misinformation to get to the more reliable information
Quote@DavidGilbert43 Thought you might like this? Being weird & thinking differently-sounds familiar... pic.twitter.com/jX5Ja0Cn1w
QuoteIt is here that the Dunning-Kruger effect comes to the fore, wherein antivaccine activists think that they understand as much or more than actual scientists because of their education and self-taught Google University courses on vaccines, that their pronouncements on vaccines should be taken seriously.
QuoteWe know how easy it is to confuse correlation with causation, to exhibit confirmation bias wherein we tend to remember things that support our world view and forget things that do not, and to let wishful thinking bias us.
QuoteThe idea, says Nosek, is that researchers "write down in advance what their study is for and what they think will happen." Then when they do their experiments, they agree to be bound to analyzing the results strictly within the confines of that original plan. It sounds utterly elementary, like the kind of thing we teach children about how to do science. And indeed it is—but it is rarely what happens.
Quote
But at any moment you're also just a few taps away from becoming an insufferable know-it-all. Searching for answers online gives people an inflated sense of their own knowledge, according to a study. It makes people think they know more than they actually do.
QuoteThe fact is that we all suffer from some subconscious biases
QuoteThere are about a 100 to consider, so start swotting up with this comprehensive list.
QuoteIntellectual humility comes in many other forms – but at its centre is the ability to question the limits of your knowledge.
QuoteFighting words. twitter.com/afrakt/status/...
QuoteHow can we get serious about creating an open, valid, and reliable scientific literature?
We recommend starting by acknowledging our moral response to the problem, and then putting it aside. It's impeding our thinking.
QuoteThe IOM report comes on the heels of 2 proposals published by the Department of Health and Human Services (HHS) and the National Institutes of Health (NIH) seeking to increase transparency of clinical trials through information submitted to ClinicalTrials.gov, the publicly accessible database run by the National Library of Medicine.
QuoteMeanwhile, the European Medicines Agency is establishing standards for transparency of clinical data for trials carried out in the European Union. These new standards are tentatively to be applied to new clinical trials beginning on or after May 26, 2016.
QuoteI know I've written about this before on the blog, but today I came across two infographics which are worth sharing on how to spot medical quackery. Ben Goldacre, author of Bad Science, classifies science reporting as falling into three categories – wacky stories, scare stories and "breakthrough" stories, the last of which he views as "a more subtly destructive category of science story".
Quoteonline community of patient experts
Quotesocial channels provide direct access to patients willing and eager to engage in the research process
QuoteA recent Twitter conversation that cast doubt on the conclusions of a genomics study has revived a debate about how best to publicly discuss possible errors in research.
QuoteThanks to Twitter and blogs, he says, "you can crowdsource discussion and analysis. I think that's very healthy for science."
QuoteRT @DrBinks: Scientists respond to BMJs recent string of ad hominem attacks on Industry funded science | The BMJ... fb.me/6FfbatfMs
QuoteBut the new guidelines — called TOP, for Transparency and Openness Promotion — represent the first attempt to lay out a system that can be applied by journals across diverse fields.
QuoteEvery week, I scour the internet for good reads (mostly science) so you don't have to. Here's this week's assortment. phenomena.nationalgeographic.com/2015/02/21/ive...
QuoteBig food, big pharma: is science for sale? bmj.com/content/350/bm... A: YES! (corrected link) ethicalnag.org/2012/06/30/big... @SusanMolchan @StuartBuck1---
QuoteWe have grown accustomed to allegations of conflicts of interest, biased research, and manipulative marketing on the part of the drug industry.
QuoteTo gain public cooperation the science must be above reproach.---
QuoteThere have been a number of articles written about how the tobacco companies bought silence, particularly from black organizations.
QuoteIndustry, of course, has the right to promote its positions, Brownell and Warner remind us, but when money flows through such organizations, their nature and intent are not apparent to the general public.
Quote#AAAAI15 Keynote Speech: The Reproducibility Crisis in Science: Causes and Consequences with Dr J. Ioannidis from @StanfordMed
QuoteMedical research is in bad shape. Fraud, bias, sloppiness, and inefficiency are everywhere, and we now have studies that quantify the size of the problem.
QuoteIn his seminal paper, "Why Most Published Research Findings are False," he developed a mathematical model to show how flawed the research process is.
QuoteIonnidas arguing that much of innovation happening outside of medical lit #AAAAI15
QuoteAlthough Theranos claims it has reinvented lab testing, making it possible to run hundreds of diagnostic tests using a single drop of blood, the article in the Journal of the American Medical Association (JAMA) points out the lack of peer-reviewed studies related to its technology.
QuoteWhat about overdiagnosis, false-positives, or the possibility of an uptick in iatrogenic causes?
QuoteTitled "Stealth Research: Is Biomedical Innovation Happening Outside the Peer-Reviewed Literature?" the article by John P.A. Ioannidis, MD
Quote from: guess on December 02, 2014, 03:24:47 PM
Out of habit I follow your filing system.
QuoteTransparency remains essential, but it isn't sufficient to eliminate bias or perception of bias.
QuoteWe believe this risk of bias is particularly important for clinical educational articles that are designed to guide patient care, when authors' biases may be less visible to general medical readers.
QuoteFrom next year our clinical education articles will be authored by experts without financial ties to industry (box).
QuoteAfter studying masters of organizational innovation for over 10 years, we've identified three key activities that truly innovative organizations like Pixar are able to do well. First, the people and groups in them do collaborative problem solving, which we call creative abrasion. Second, they try things and learn by discovery, demonstrating creative agility. Third, they create new and better solutions because they integrate existing ideas in unanticipated ways, practicing creative resolution.
QuoteNew free @nature collection: Statistics for biologists (nature.com/collections/qg...) - blogs.nature.com/ofschemesandme... @NatureBlogs pic.twitter.com/z7FlousvgY
QuoteIrreproducibility issues affecting basic research in biology can be traced to a variety of common causes. One of them is the misguided use of statistics.
QuoteGr8! Free @JohnsHopkinsSPH online courses: statistics coursera.org/course/statrea... & systematic reviews coursera.org/course/systema... HT @lgcuervoamore
QuoteTo maintain the integrity of science research and the public's trust in science, the scientific community must ensure reproducibility and replicability by engaging in a more preventative approach that greatly expands data analysis education and routinely uses software tools.
Quote"In the past six years, we've found that more and more patients are trying to access research studies written about them, including studies where they were participants. In addition, they are increasingly capable of understanding them. Yet closed access is locking them out of better understanding their conditions and their choices."
QuoteGood science is how we avoid fooling ourselves, even when we have incentive to do so, financial and otherwise. The true merits of a study stem from its design and methods, so long as they are fully and transparently reported — and there are many ways we could do a better job of that.
QuoteYou might think science is science, but some evidence is ranked higher in the scientific community than others, and having an awareness of this can help you sort the science from the pseudoscience when it comes to various internet claims.
QuoteA series of articles in the New England Journal of Medicine has questioned whether the conflict of interest movement has gone too far in its campaign to stop the drug industry influencing the medical profession. Here, three former senior NEJM editors respond with dismay
Quotewe should encourage all medical journals to separate the functions of evidence generation from those of appraisal
QuoteAs Ben Goldacre says in the introduction to his new book Bad Pharma, "Drug companies around the world have produced some of the most amazing innovations of the past fifty years, saving lives on an epic scale. But that does not allow them to hide data, mislead doctors, and harm patients."
Quotethat is a fairly civil way of stating things, given what scientists are like
QuoteI am afraid this manuscript may contribute not so much towards the field's advancement as much as toward its eventual demise.
QuoteYour ability to collate + synthesize material from a clear + critical perspective is first rate and your writing is a pleasure to read.
QuoteI would personally hope that others can share your ideas through your writing.
QuoteWhen I give a presentation and mention the 97% expert consensus on human-caused global warming, I'm often asked, "what's the deal with the other 3%?".
QuoteLast week, Spencer wrote a white paper for the Texas Public Policy Institute (TPPI) outlining the contrarian case against climate concerns. TPPI is part of the web of denial, having received substantial funding from both the tobacco and fossil fuel industries, including $65,000 from ExxonMobil and at least $911,499 from Koch-related foundations since 1998, and over $3 million from "dark money" anonymizers Donors Trust and Donors Capital Fund.
QuoteRT @HubJHU: @JohnsHopkins researchers use @twitter for insight on #PTSD, #depression, mental illness hub.jhu.edu/2014/12/09/twi... ...
QuoteThe computer algorithms used to collect mental health data from tweets look for words and language patterns associated with these ailments, including word cues linked to anxiety and insomnia, and phrases such as "I just don't want to get out of bed."