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Topic summary

Posted by Macabre
 - January 03, 2014, 01:21:19 AM
chamazulene
Matricine


http://www.ncbi.nlm.nih.gov/m/pubmed/7997466/
Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation.

AuthorsSafayhi H, et al. Show all Journal
Planta Med. 1994 Oct;60(5):410-3.

Affiliation
Abstract
Matricine and its transformation product chamazulene are constituents of chamomile extracts. Both have been demonstrated to exert anti-inflammatory activity in vivo. Since preparations from chamomile are used for the treatment of inflammatory skin and bowel diseases, we studied the effects of these compounds on the leukotriene production in neutrophilic granulocytes. Chamazulene inhibited the formation of leukotriene B4 in intact cells and in the 105,000 x g supernatant fraction in a concentration-dependent manner. The IC50 values were 15 and 10 microM, respectively. Matricine showed no effect up to 200 microM. Chamazulene (IC50: 2 microM), but not matricine, blocked the chemical peroxidation of arachidonic acid. Additionally, matricine (up to 200 microM) had no effects on the cyclooxygenase and 12-lipoxygenase activities in human platelets. Therefore, it is concluded that chamazulene, but not matricine, may contribute to the anti-inflammatory activity of chamomile extracts by inhibiting the leukotriene synthesis and additional antioxidative effects.

PMID 7997466 [PubMed - indexed for MEDLINE]




http://www.ncbi.nlm.nih.gov/m/pubmed/15311845/
Supercritical carbon dioxide extraction of chamomile flowers: extraction efficiency, stability, and in-line inclusion of chamomile-carbon dioxide extract in beta-cyclodextrin.

AuthorsKaiser CS, et al. Show all Journal
Phytochem Anal. 2004 Jul-Aug;15(4):249-56.

Affiliation
Abstract
Posted by Macabre
 - January 03, 2014, 12:49:19 AM
Matricaria recutita

Chamaemelum
Posted by Macabre
 - January 02, 2014, 09:38:56 PM
Wow. Thank you. It is also known as:

levomenol
Posted by twinturbo
 - January 02, 2014, 08:56:14 PM
bisabolol. It's in the Aquaphor line.
Posted by Macabre
 - January 02, 2014, 07:43:12 PM
Chamomile (you never guessed that one)

Language variants: Camomilla, Camomille, Kamillen, Kamille,

Manzilla (Spanish for Chamomile)

Cinnal

Hexyl cinnamaldehyde is found in the essential oil of chamomile




Apigenin is a flavonoid compound found in chamomile (and also parsley and celery)
Versulin ?? is possibly the same as Apigenin?


I'm not sure if this will be helpful, but I want to bookmark this:

http://www.chemspider.com/Chemical-Structure.1267362.html