Food Allergy Initiative

You might want to check out

http://www.seafac.org/seattle-food-allergy-consortium/consortium-members/

Wa-feast isn't going to recommend a dr to you - but you can talk to members on the the yahoo list or fb - I think I posted links above.

What is FAI?

Yes, FAI had a branch office in the Sea-Tac area. There will be some good allergists there.

Contact WA-FEAST-- they'll know who is in your area.   

I got my sons result paperwork in the mail. His .48 to ara h 2 is actually considered to be a low positive result by the lab. The doctor must have read the results wrong. 

I guess I am looking for a new allergist now... wish there was a "top" food allergy specialist in my area... it doesn't look like there is an allergy department at Seattle Children's hospital which is disappointing. Supposedly they are looking for funding and want to do desensitization therapy  in the future but not now. I found a place in town that seems to do food allergy research but doesn't actually treat patients.

Thanks Stinky!   

Quote
And what about the following... am I reading this right? My take is that with my son's .48 result to arah 2 he has a 70 to 90% chance of reacting to the ingestion of peanut? Why on the world would his allergist be recommending a food challenge if this is correct???

This is why I think it might well be helpful to see a real specialist in FOOD allergy, who is up to date on current research and stuff.  It's going to come down to very specific history details and a lot of other factors, probably... including your own risk tolerance (and the doc's).

KNOWING what kind of threshold you're dealing with might be worth it if your risk is 50-50 and your doctor is very conservative with respect to symptoms (that is, would stop the challenge before the development of really obvious objective symptoms).

I didn't read the whole thread.....I'll come back to it....but thanks to a pm from cm I can offer some quick help. 

I've heard
http://www.allassoc.com/dr-kevin-dooms/ 

is good

We go to http://www.nwasthma.com/providers/doctors/thao-ngoc-tran-md  and like her very much.  She's up on the research and conservative which worked for my family

There really are a lot of options.   Where is WA are you looking?  www.wafeast.org has a listserv and a closed fb page both would be a great resource for you.

And what about the following... am I reading this right? My take is that with my son's .48 result to arah 2 he has a 70 to 90% chance of reacting to the ingestion of peanut? Why on the world would his allergist be recommending a food challenge if this is correct???

Info from the ask the expert section of American Academy of Allergy, Asthma and Immunology- found at: http://www.aaaai.org/ask-the-expert/component-testing-peanut.aspx


Significance of component testing to peanut
Question:
10/21/2013
I would like some help interpreting component testing for peanut. I have a 32 yr-old male with a 20 yr history of immediate vomiting and angioedema of the throat when he ate a peanut cookie. Since then he has avoided peanut altogether and he wished to find out if he was still allergic. His skin test was a 4+ with a wheal of 14 mm greater than negative control, histamine was 5 mm wheal. His component tests for Ara h1 and 3 were <0.10 (ref range from Quest Diagnostics) and Ara h2 was 0.31, Ara h9 was 0.90 and Ara h8 was 9.97. Based on these results and the history should he continue to avoid peanut despite being 20 years ago or based on his tests his Ara h8 reveals that he may have developed tolerance.

Answer:
Thank you for your inquiry.

Based upon the results you have supplied, your patient has a high likelihood of reacting to the ingestion of peanuts. An Ara h2 level of about 0.3 has a 70 to 90% predictive value of a reaction upon the ingestion of peanuts (1-3). This would not of course preclude an oral challenge, but the decision to do so would be based upon your own assessment of the risk/benefit ratio and a discussion of risk/benefit with your patient. If you decided to do a challenge, I would suggest doing it outside of the tree pollen season (wintertime) to minimize the chance of an oral allergy syndrome reaction secondary to the Ara h8 sensitization.

Finally, it should always be noted that component testing gives one statistical risks, but not definitive information. Anaphylaxis can occur to any component including those such as Ara h8 which are more classically associated with oral allergy syndrome. In this regard, for your convenience, I have copied below an entry regarding a similar question that was posted to our website 6/26/2013.

Thank you again for your inquiry and we hope this response is helpful to you.

References:

1. Klemans et al: Ara h 2 Is the Best Predictor for Peanut Allergy in Adults, Journal of Allergy and Clinical Immunology: In Practice 11 October 2013.

2. Lieberman J et al:The Utility of Peanut Components in the Diagnosis of IgE-Mediated Peanut Allergy Among Distinct Populations Journal of Allergy and Clinical Immunology: In Practice Vol. 1, Issue 1, Pages 75-82, 2013.

3. Keet et al: Evaluation of Ara h2 IgE thresholds in the diagnosis of peanut allergy in a clinical population. Journal of Allergy and Clinical Immunology: In Practice Vol. 1, Issue 1, Pages 101-103.

Previous posting to Ask the Expert website:
The value of component testing in predicting a systemic reaction to peanut

Question:
6/26/2013
Seven-year-old boy with significant seasonal allergic rhinitis (very allergic to oak, and Birch) and no history of food allergies ate honey roasted peanuts . Within 5 minutes he started with a barky, croupy cough and then developed very significant skin pruritus. He was itching very hard over his chest and neck. Then the cough got worse and he sounded wheezy. He was given a dose of Benadryl, and fortunately he did not have any further complications. The results of my evaluation are: Skin test to Peanut 2+/4+. sIgE to peanut 1.02 kU/L. Ara H 1,2,3,9 <0.1. Ara H 8 24.1 kU/l. According to the review, he should be at low risk for anaphylaxis but the initial reaction is definitely much more than oral allergy syndrome. What would you advise?

Answer:
Thank you for your inquiry.

Your interpretation of the literature is correct in that "classically" the pattern of specific IgE to peanut components seen in your patient would be more likely to predict that only oral symptoms, and not a systemic reaction, would occur upon ingestion of peanuts. However, it is important to understand that this classical interpretation is based only on statistical probabilities. By this I mean that children demonstrating only specific IgE to Ara h 8 are less likely to exhibit a systemic reaction than children exhibiting specific IgE to Ara h 2, for example. Nonetheless, systemic reactions can occur with isolated sensitivity to Ara h 8.

As you can see from the abstract (Asarnoj, et al.) copied below, systemic reactions can occur in children with isolated Ara h 8 sensitivity. This is seen clearly in Figure 3 of this article.

The most reliable test to discern whether a child will exhibit a systemic reaction to peanut is an actual oral challenge. In essence, the reaction exhibited by the child described in your inquiry should be taken at "face value," and the child, at least for the present, should be considered allergic to peanuts. It is clear that patients who have negative skin tests as well as serum specific IgE to foods may still exhibit allergic reactions upon oral food challenge (see Journal of Allergy and Clinical Immunology reference copied below).

Thus, in summary, the results of serum specific IgE testing both in testing to "whole" and component testing, simply serve as guidelines, pointing out the relative risks of a reaction upon ingestion. They are not intended to confer 100 percent predictability as to whether or not a patient will react to the ingestion of the food in question.

Thank you again for your inquiry and we hope this response is helpful to you.

Allergy. 2010 Sep;65(9):1189-95. doi: 10.1111/j.1398-9995.2010.02334.x. Epub 2010 Feb 8.
IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds.
Asarnoj A, Movérare R, Ostblom E, Poorafshar M, Lilja G, Hedlin G, van Hage M, Ahlstedt S, Wickman M.
Source
National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Abstract
Background: Allergen-specific IgE testing is often performed with crude peanut extract, but the results may be difficult to interpret because of cross-reactions between peanut and other plant allergens. The aim was to investigate IgE reactivity to peanut allergen components in children from a birch-rich region in relation to pollen sensitization and peanut symptoms.
Methods: From a birth cohort, clinical parameters were obtained through questionnaires and IgE antibody levels to peanut and birch pollen were measured. Different peanut/birch sensitization phenotypes were defined among 200 selected children. IgE reactivity to peanut and pollen allergen components was analysed using microarray technique.
Results: Peanut symptoms were reported in 87% of the children with IgE reactivity to any of the peanut allergens Ara h 1, 2 or 3 but not to Ara h 8 (n = 46) vs 17% of children with IgE reactivity to Ara h 8 but not to Ara h 1, 2 or 3 (n = 23), P < 0.001. Furthermore, symptoms were more severe in children with Ara h 1, 2 or 3 reactivity. Children with IgE reactivity both to Ara h 2 and to Ara h 1 or 3 more often reported peanut symptoms than children with IgE only to Ara h 2 (97%vs 70%, P = 0.016), particularly respiratory symptoms (50%vs 9%, P = 0.002).
Conclusions: IgE analysis to peanut allergen components may be used to distinguish between peanut-sensitized individuals at risk of severe symptoms and those likely to have milder or no symptoms to peanut if sensitized to pollen allergens and their peanut homologue allergens.

J Allergy Clin Immunol. Author manuscript; available in PMC 2012 November 1.
Published in final edited form as:
J Allergy Clin Immunol. 2011 November; 128(5): 1120–1122.
Published online 2011 August 11. doi: 10.1016/j.jaci.2011.07.012
PMCID: PMC3205298
NIHMSID: NIHMS319256
Outcomes of office-based, open food challenges in the management of food allergy
Jay A Lieberman, MD, Amanda L Cox, MD, Michelle Vitale, RN, and Hugh A Sampson, MD

Sincerely,
Phil Lieberman, M.D.

That would be great thanks!

Stinky is stinky-- long story involving multiple devices and passwords, and never logging out.  LOL.

I'll let her know that she should visit this thread, okay?

accidental post sorry

I found the following at Quest Diagnostics web site: http://www.questdiagnostics.com/testcenter/testguide.action?dc=TS_Peanut_Component_Panel

Unfortunately, I still don't quite know what to make of the borderline result to ara h 2 

But the following (found near the end of the quest diagnostics info) posted above makes me feel a food challenge isn't the way to go at this point:

Patients with only Ara h 8 sensitization may consider taking an oral food challenge test, and, if negative, they may not have to avoid peanuts or peanut-containing foods.

I get that borderline isn't the same as a positive reaction but it isn't exactly negative either is it???

BTW there are two members that go by "stinky"... stinky 6 and stinky 10 any idea which one lives in Washington state?

info copied below:

Peanut Component Panel
 
Clinical Use
Assess risk of severe allergic reaction vs mild or localized reaction to peanut exposure
Clinical Background
The prevalence of peanut allergy in North American school-aged children is approximately 1%.1 This allergy is often a lifelong condition,2 and is the most common food-related cause of fatal allergic reactions in Western countries.3 Peanut allergy is typically diagnosed based on clinical history and peanut sensitization (ie, IgE antibody response to peanut extract during blood or skin prick testing). Sensitization, however, does not correlate with allergic symptoms in a large percentage of patients,4,5 and as many as 77% of peanut sensitized patients may not be at risk for a systemic reaction.6 This may be because most tests are based on crude natural peanut extracts that contain allergenic and non-allergenic components, and some of these components may crossreact with pollen or other allergens.
Over 13 allergenic components have been identified in peanuts.7 Of these, Ara h 1, 2, 3, 6, 8, and 9 are considered the most important markers of peanut sensitization and are predictive of an allergic response. Ara h 1, 2, and 3 are seed storage proteins, and sensitization to them is associated with a high risk of a systemic allergic reaction: 87% of the children with IgE reactivity have allergic symptoms, including anaphylaxis.8 Ara h 2 is a more important predictor of clinical peanut allergy than Ara h 1 and 3, and is the one most often associated with severe reactions.6 Ara h 6 sensitization is associated with IgE antibodies that crossreact with Ara h 29; rarely does sensitization to Ara h 6 occur in the absence of sensitization to Ara h 2.10
Ara h 8 is a pathogenesis-related (PR)-10 protein, and sensitization to it is associated with a low risk of systemic reaction and a moderate risk of mild, localized symptoms (ie, oral allergy syndrome). In a study of 144 children with IgE antibodies to Ara h 8 (but not Ara h 1-3), 89% were either peanut consumers or did not react to an oral food challenge with peanuts, while 9.7% of the children had mild oral cavity symptoms and 1 child developed mild gastrointestinal symptoms.11 Ara h 8 crossreacts with pollens (eg, Birch and Birch-related tree pollen); Mittag et al showed that 20 patients with Birch pollen allergy and IgE antibodies to Ara h 8 exhibited oral allergy syndrome when exposed to peanut.12
Ara h 9 is a lipid transfer protein, and sensitization to it can result in systemic reactions, including anaphylaxis; 38% (6/16) of subjects sensitized to Ara h 9 were found to have severe symptoms after peanut exposure.9 People sensitized to Ara h 9 are often also sensitized to Ara h 1-3.13 Ara h 9 is not specific to peanut; it crossreacts with fruits with pits (eg, peaches).14
The Peanut Component Panel tests for IgE antibodies to peanut allergens Ara h 1, 2, 3, 8, and 9. Identifying sensitization to peanut component allergens can assist is assessing a patient's risk for a severe systemic reaction.
Individuals Suitable for Testing
Individuals with a history of peanut sensitivity or with documented sensitization by blood or pin prick testing
Method
Fluorescent enzyme immunoassay (FEIA) measurement of IgE antibodies to Ara h 1 (f422), Ara h 2 (f423), Ara h 3 (f424), Ara h 8 (f352), and Ara h 9 (f427)
Analytical sensitivity: <0.1 kU/L
Interpretive Information
Reactivity to Ara h 1, 2, or 3 is associated with a high risk for systemic reaction, including anaphylaxis. Reactivity to Ara h 9 is associated with a variable risk for systemic reaction, including anaphylaxis. Patients who exhibit reactivity to Ara h 1, 2, 3, and/or 9 should be counseled to avoid peanuts, foods that contain peanut products, and foods that have been processed in plants that also process peanuts.
Reactivity to Ara h 8 and nonreactivity to Ara h 1, 2, 3, and 9 indicates a low risk of a systemic allergic reaction. Patients with only Ara h 8 sensitization may consider taking an oral food challenge test, and, if negative, they may not have to avoid peanuts or peanut-containing foods.15
As with all diagnostic testing, results should be interpreted in light of a patient's history, physical examination, and results of other diagnostic testing.

You might try to send a PM to Stinky and ask if she has someone she'd recommend to you-- the very well-respected allergist in the western part of the state (that I knew about) has very sadly passed away.  :/

I'd be interested in that info too, now that I think about it, as we are potentially looking to relocate in a few years, and had been considering the north sound.

Quote from: CMdeux on March 28, 2014, 02:35:37 PM
That's why I would rather KNOW.  It's not that the answer will necessarily be the one that we'd all like-- but that if it's "avoid-avoid-avoid" then you know that you're doing it because you MUST.  Not because you're afraid of the unknown, but because of a fear that is completely rational and well-considered. That secure knowledge will make you a rock-solid advocate for your child-- and that certainty will be something that you'll both need throughout his life.

Quote from: CMdeux on March 28, 2014, 02:35:37 PM
But the only way that I'd be comfortable with this kind of challenge is under the care of a doctor that I felt was TOP-notch, and whom I trusted implicitly.   Maybe even then-- I'd want to do it slowly, with a lot of safety protocols in place.  Maybe even in a hospital setting.

Yes.  Great points.

Quote from: twinturbo on March 28, 2014, 01:16:56 PM
Links,etc. (member name) has some not surprisingly good links on peanut challenges and what qualifies as a pass.

-------------------

This is the main thread that I'm putting together regarding challenges.

Oral Food Challenges - Links & General Info

I am thankful that we were able to do challenges for my dd - it's made a big difference in our lives.

As with any medical procedure, the risks/benefits have to be weighed.