QuoteIt is epinephrine underuse that has consistently been shown to be the issue in anaphylactic emergencies,[2] and overdose is actually quite rare. The standard adult dose of self-injecting epinephrine (0.3 mg of 1:1000 epinephrine) raises the level of epinephrine in the body from an average of 0.035 ng/mL to about 10 times that amount.[7] It would require more about 20 such injections to reach a toxic level.