Tweeted by @AllergyEducator


"Cross reactivity of seed allergens"
http://www.aaaai.org/ask-the-expert/cross-reactivity-seed.aspx?utm_content=buffer77698&utm_medium=social&utm_source=linkedin.com&utm_campaign=buffer

QuoteI think your summary of the literature suggesting that we do not have a great deal of detail on the cross reactivity of ingested seeds is a fair assessment. The 2S, 7S, 11S storage proteins are common to many seeds and could provide cross reactivity. However, the clinical evidence of the importance of this cross-reactivity is not well substantiated.

sesame allergy patient study uk


"Sesame allergy in Britain: a questionnaire survey of members of the Anaphylaxis Campaign."
http://www.ncbi.nlm.nih.gov/pubmed/15787876

QuoteSesame should be identified clearly as an ingredient and separately from nuts and peanuts when it may be an allergen contaminant. People at potential risk need clear allergy diagnosis and informed guidance to enable them to avoid this key allergen more easily.

sesame seed study.

"Clinical Characteristics Of - And Predictive Diagnostic Factors For - Sesame Seed Allergy In
Food-Allergic Children"

Quotea significant proportion of sesame-seed-allergic children were able to tolerate low amounts of sesame ingestion. This seems to be a common clinical finding in sesame allergy, perhaps reflecting peculiarities of sesame allergens and digestive processing thereof.

Quotetolerance of loose seeds does not always confirm tolerance of sesame concentrates

Just a reminder .... sesame-allergic people should strictly avoid all sesame, including cross-contamination, unless their allergist tells them otherwise.

"Oleosines in sesame allergy"
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3723685/

QuoteOleosins have been described by others [2], and are important allergens from sesame seed. Since they are hydrophobic, they are not present at commercial extracts or extract prepared from sesame seed in saline, or the CAP system extract.

"Sesame allergy: a growing food allergy of global proportions?"
http://www.ncbi.nlm.nih.gov/pubmed/16095135

Quote
Evidence was found for increased reporting of sesame allergy during the past 5 decades, with reports mostly from developed countries. Clinically, most sesame allergy was presented in at least 2 major forms: (1) immediate hypersensitivity, often expressed as systemic anaphylaxis, associated with positive skin prick test and/or IgE antibody test results to sesame proteins with some cross-reactivity with other foods, and (2) delayed hypersensitivity to lignin-like compounds in sesame oil clinically expressed as contact allergic dermatitis. There were a few cases of immediate hypersensitivity to sesame with negative skin prick test and/or IgE antibody test results that were confirmed by oral challenge tests.

This is from 2003 ... I'm not sure if there has been more research since then.  Not a big sample size for sesame.


"Thresholds of clinical reactivity to milk, egg, peanut and sesame in immunoglobulin E-dependent allergies: evaluation by double-blind or single-blind placebo-controlled oral challenges."

http://www.ncbi.nlm.nih.gov/pubmed/12911777

Quote
Data from 125 positive oral challenges to egg, 103 to peanut, 59 to milk and 12 to sesame seeds were analysed. Haemodynamic modifications were observed in 2%, 3%, 1.7%, and 8% of the oral challenges (OCs) to egg, peanut, milk and sesame, respectively. Respiratory symptoms were observed in 12%, 20%, 10% and 42% of egg, peanut milk and sesame allergies, respectively. A cumulative reactive dose inferior or equal to 65 mg of solid food or 0.8 mL of milk characterized 16%, 18%, 5% and 8% of egg, peanut, milk and sesame allergies, respectively. 0.8% of egg allergies, 3.9% of peanut allergies, and 1.7% of milk allergies reacted to 10 mg or less of solid food or to 0.1 mL for milk. The lowest reactive threshold has been observed at less than 2 mg of egg; 5 mg of peanut, 0.1 mL of milk and 30 mg of sesame seed. Ten out of 29 OC with peanut oil, two out of two OC with soy oil and three out of six OC with sunflower oil were positive. Five out six OC with sesame oil were positive: 1 and 5 mL induced an anaphylactic shock.

"Sesame Allergy: Role of Specific IgE and Skin Prick Testing in Predicting Food Challenge Results"

Perdita Permaul, MD,ab Lisa M. Stutius, MD,ab William J. Sheehan, MD,ab Pitud Rangsithienchai, MD, MA,ac Jolan E. Walter, MD, PhD,ab Frank J. Twarog, MD, PhD,ab Michael C. Young, MD,ab Jordan E. Scott, MD,ab Lynda C. Schneider, MD,ab and Wanda Phipatanakul, MD, MSab

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131114/

Quote
Although our study is limited by a small sample of cases, there is an inclination for predicting the outcome of a sesame food challenge with SPT based on our results

Quote
Notably, 29% of sesame allergic patients had a sesame-specific IgE < 0.35 kUA/L. This is in contrast to the findings of Zavalkoff et al. who reported a cut-off < 0.35 kUA/L as being useful in excluding a diagnosis of sesame allergy.

"Demographic Predictors of Peanut, Tree Nut, Fish, Shellfish, and Sesame Allergy in Canada"

M. Ben-Shoshan,1 D.W. Harrington,2 L. Soller,3 J. Fragapane,3 L. Joseph,3, 4
Y. St. Pierre,3 S. B. Godefroy,5 S. J. Elliott,6 and A. E. Clarke3, 7

http://www.medicine.mcgill.ca/epidemiology/joseph/publications/Medical/benshoshan2012.pdf

"Food Allergy in Kids Not Being Optimally Diagnosed"
http://www.medscape.com/viewarticle/753505

Quote
The survey involved 40,104 children; of these, investigators identified 3339 children with food allergy.

Quote
oral food challenge was done in just 15.6% of children

Quote
Formal diagnoses were most frequently confirmed by oral food challenge for milk allergy (22.4%), soy (19.2%), peanut (16.1%), wheat (15.5%), shellfish (14.4%), tree nut (12.6%), egg (12.4%), sesame (11.2%), and fin fish (9.1%).

LinksEtc
Member
Posted: 09.08.2011 at 11:29:09

---

I know this is a more general research article, but I wanted to keep track that sesame was a common allergen that was being challenged.

Outpatient open oral food challenges – feasible and "feed-able"
http://www.aaaai.org/global/latest-research-summaries/Current-JACI-Research/outpatient-open-oral-food-challenges-feasible-an.aspx

Quote
reviewed 22 months worth of successive open OFCs performed at a university-based pediatric allergy outpatient clinic (Mount Sinai School of Medicine, New York, NY)

---

LinksEtc
Member
Posted: 07.13.2011 at 07:07:08

---

"Skin Prick Test Wheal Size Thresholds Identified"

22-Apr-11

Elsevier Global Medical News

BY SHERRY BOSCHERT

http://www.medconnect.com.sg/tabid/92/s5/Allergy-Immunology/ct1/c40916/Skin-Prick-Test-Wheal-Size-Thresholds-Identified-/Default.aspx

Quote
A 9-mm wheal after skin prick testing provided a 95% positive predictive value for egg or peanut allergy in an analysis of data from 5,000 12-month-old infants

Quote
71 with sesame challenges. None of the wheal sizes after sesame challenges reached a 95% positive predictive value for allergy, said Dr. Gurrin of the University of Melbourne.

---

LinksEtc
Member
Posted: 07.13.2011 at 06:39:20

---

"Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants"

The Journal of Allergy and Clinical Immunology
Volume 127, Issue 3 , Pages 668-676.e2, March 2011

www.jacionline.org/article/S0091-6749(11)00135-7/abstract

Quote
Recruitment occurred at childhood immunization sessions in Melbourne, Australia.

Quote
Amongst 2848 infants (73% participation rate), the prevalence of any sensitization to peanut was 8.9% (95% CI, 7.9-10.0); raw egg white, 16.5% (95% CI, 15.1-17.9); sesame, 2.5% (95% CI, 2.0-3.1); cow's milk, 5.6% (95% CI, 3.2-8.0); and shellfish, 0.9% (95% CI, 0.6-1.5). The prevalence of challenge-proven peanut allergy was 3.0% (95% CI, 2.4-3.8); raw egg allergy, 8.9% (95% CI, 7.8-10.0); and sesame allergy, 0.8% (95% CI, 0.5-1.1).

--------------

The link isn't working again, but you can copy and paste the entire link.

« Last Edited by LinksEtc 07.14.2011 at 10:05:30 »

---

LinksEtc
Member
Posted: 06.01.2011 at 09:24:00

---

Thanks CM!

---

CMdeux
Moderator1
Posted: 05.31.2011 at 01:49:38

---

Thank you so much for this!! We should definitely create a linker thread from the research forum to this thread, but I think it is a terrific idea to house individual allergen research like this.

So much of the clinical research is becoming allergen-specific. It's really a wealth of information, and I'm so encouraged that the nuances between food allergens are being explored (for example, the conventional wisdom re: which allergen proteins are the "important" ones in egg, milk, and peanut allergy) but it sure makes it a lot denser in this forest. 

Parsing it out like this is very helpful to let us see the individual grove that we happen to be standing in, as we look at all these trees. THANK YOU!!

---

"To travel hopefully is a better thing than to arrive." -Robert Louis Stevenson

USA