QuoteHowever, once histamine is formed, it cannot be eliminated by heat (including retorting) or freezing.
Quote
On the other hand, it must be stressed that histamine is a very stable substance. Once
produced, it cannot be destroyed with usual thermal procedures like cooking, frying or hot
smoking (Lehane and Olley, 2000). Long-term stability of histamine diphosphate solutions
used for bronchoprovocation tests in humans was shown for at least 8 weeks at 4◦C and12 months at−20◦C.
Histamine degradation by light exposure was determined in sterile
histamine solutions (Marshik et al., 1999; Marwaha and Johnson, 1986).