@allergistmom is tweeting with others at a conference today, very interesting to follow #AAAAI
now!
Thanks!! :thumbsup:
I came to post this. But maybe we should hanger subject lines? You don't have to be a twitter fan or user. Just folllow the hashtag. #aaaai
"@allergistmommy: As many asthmatics have confluence of risk factors (steroids, PPI, etc) consider screening w/ bone density at regular intervals. #AAAAI"
@allergistmommy: Dysfunctional breathlessness among the most common add'l dx in pts w/ refractory asthma. More common than vocal cord dysfunction. #AAAAI
@allergistmommy: Dysfunctional breathlessness among the most common add'l dx in pts w/ refractory asthma. More common than vocal cord dysfunction. #AAAAI
@allergistmommy: Dysfunctional breathlessness can be treated with psychotherapy, biofeedback, and speech therapy. #AAAAI
@allergistmommy: If FEF50/FIF50 ratio is >150% predicted, strongly indicative of vocal cord dysfunction. #AAAAI
@allergistmommy: Restrictive pattern on spirometers: does not always correlate with true restrictive disorder. #AAAAI
@allergistmommy: Flexible laryngoscopy or video stroboscopy needed to work through the dx of extrathoracic obstruction. Don't assume VCD. #AAAAI
@allergistmommy: As allergists, we usually deal w/ obstructive lung disease. Remember: restrictive lung dz is part of the Ddx for dyspnea and cough. #AAAAI
@allergydoc4kidz: Next up: Wesley Burks on OIT for foods #AAAAI
@allergydoc4kidz: PN allergy increasing in prevalence, more commonly assoc with anaphylaxis, and inciting threshold often lower than other foods #AAAAI
@allergydoc4kidz: Early studies targeted 300mg PN maintenance, low but above 100mg threshold for most pts #AAAAI
@allergydoc4kidz: Risk for unanticipated OIT rxn (not during buildup): fever, viral infection, exercise, menses #AAAAI
@allergydoc4kidz: Sx with 15-25% of OIT doses, but severe in <1% #AAAAI
@allergydoc4kidz: Drop out rate of 10-20% often due to delayed GI sx early on #AAAAI
@allergydoc4kidz: 93% able to tolerate ~13 PN after completing OIT trial (had reacted to 1/6 of a PN prior) #AAAAI
@allergydoc4kidz: Corresponding changes in SPT, basophil responses, IgE/IgG4 #AAAAI
@allergydoc4kidz: f/u DBPC study with 4000mg PN maintenance, substantially greater threshold after compared to placebo #AAAAI
@allergydoc4kidz: Th2 responses decrease, with transient rise in Tregs with PN-OIT #AAAAI
@allergydoc4kidz: Desensitization vs tolerance induction - can tx be stopped without recurrence? #AAAAI
@allergydoc4kidz: 19 pts on OIT for 33-70 mths, off for 4 weeks, 11 remained tolerant to 5000mg PN #AAAAI
@allergydoc4kidz: If baseline PN-IgE >85, less likely to develop true tolerance (all have some decrease in sIgE over time) #AAAAI
@allergydoc4kidz: Milk-OIT for 5-6 months with 500mg maintenance dose #AAAAI
@allergydoc4kidz: 19 pts with 40mg threshold at entry, increased to 4000mg after tx for 12 active milk-OIT, no change for 7 controls #AAAAI
@allergydoc4kidz: Milk SLIT vs OIT; SLIT alone unsuccessful, high-dose OIT after SLIT 80% success (more side effects) #AAAAI
@allergydoc4kidz: Pre-tx with anti-IgE for milk rush OIT; 9/10 able to achieve 1000mg 1st day (usually <50) #AAAAI
@allergydoc4kidz: Egg OIT multicentre DBPC 10 month trial plus extension, 2000mg maintenance dose, rpt challenge after 4-6 wks off tx #AAAAI
@allergydoc4kidz: Small SPT at 22 months correlated with functional tolerance to eggs, study still underway #AAAAI
@allergydoc4kidz: In various OIT studies: SPT drops, early IgE rise followed by gradual decline, tolerance not well established in blinded studies #AAAAI
In general I find Twitter incredibly annoying. But THIS is awesome.
Thanks,
Sue
This
Quote19 pts on OIT for 33-70 mths, off for 4 weeks, 11 remained tolerant to 5000mg
Is fairly disheartening, really.
It suggests pretty strongly that around half of PA patients probably
cannot be truly "desensitized" unto tolerance. :-/ Makes me think (personally, after looking at all this science and research for over a decade now) that a LOT more basic research is needed in order to tease apart just who is and is not likely to benefit from this kind of intervention.
I mean, I suppose that it's better to need daily dosing
forever than to be at risk of fatal anaphylaxis from an inadvertent exposure. But for female patients, that may not be so simple, either--
Quote
@allergydoc4kidz: Risk for unanticipated OIT rxn (not during buildup): fever, viral infection, exercise, menses #AAAAI
Later in the session someone is presenting about an epicutaneous study. I had to map. Am hope sick.
But I'm home sick and wanted To nap while it was raining and thundering.
More later.
And really---Nyone can follow things in real time order after the fact.
You can use www.tweetgrid.com (http://www.tweetgrid.com) and use a 1x1 frame and put it the hashtag and just see posts. It's like listening in on a conversation.
I need to see what the abbreviation tx means (since I'm prett sure they're not referring to Texas, even tho it's Mar 2). I was assuming tanox as a further abbreviation of zolair. But I could be wrong. I do know that there has been an OIT/zolair combo trial at Duke.
I gather sx=symptom, fx=function. I know I've seen both in allergists tweets. I follow these two people all the time, btw. Since the last AAAAI meeting.
Could be 'treatment' Mac.
this is the 2nd conference i have followed, its fasinating to follow, and of course picking up new info along the way.
do we have a thread giving our twitter names so that we can all follow when another conference crops up?
No I don't think so. Mine would be too personally revealing for this place as it gives my name.
But you and I are following each other. :)
I'm about to post a bit more.
Please remember that these are people basically taking notes of a conference session via twitter. KNow there can be a discrepancy between what the speaker is saying/what the allergist is hearing/what the allergist is typing.
READ FROM THE BOTTOM UP I am on my laptop rather than my phone, and it's easier to copy all at once. So the top tweet is the most recent.
-----------------------------
@allergydoc4kidz
2 points from baked milk talk: 1) challenge everyone irrespective of sIgE levels, 2) maintain regular (3x/day) intake if successful #AAAAI
@allergydoc4kidz
Enhanced IL-6 release may help sustain Th17 cells and maintain homeostasis #AAAAI
@allergydoc4kidz
IL-6 enhancement from Treg and mast cells seems TGF-B dependent#AAAAI
@allergydoc4kidz
Staphylococcal endotoxin seems an important cofactor in sensitization models, and clearly NB in atopic dermatitis #AAAAI
@allergydoc4kidz
Numbers of Treg not altered, but functional capacity diminished following oral Ag sensitization #AAAAI
@allergydoc4kidz
Experimental food allergy associated with diminished Treg-associated genes in gut #AAAAI
@allergydoc4kidz
Induction of specific Treg cells and clonal deletion of specific Th2 cells involved in development of tolerance #AAAAI
@allergydoc4kidz
Describes regulatory Th2 cells, with high IL-10 production, and IL-5 negative Th2 cells #AAAAI
@allergydoc4kidz
T cell phenotypes are not static/fixed, they can transform under various circumstances #AAAAI
@allergydoc4kidz
Next up, Paul Bryce on T cell heterogeneity in tolerance #AAAAI
@allergydoc4kidz
Regular intake of baked milk appears to accelerate development of unheated milk tolerance compared with strict avoidance #AAAAI
@allergydoc4kidz
Baked milk-tolerant subjects have increased specific Tregs in circulation #AAAAI
@allergydoc4kidz
Basophil reactivity declines with intake of baked milk products #AAAAI
@allergydoc4kidz
No single informative epitope has been found to distinguish between phenotypes #AAAAI
@allergydoc4kidz
Greater diversity and higher affinity IgE binding in persistent CMA#AAAAI
@allergydoc4kidz
Greater IgE binding stability over time associated with CMA persistence #AAAAI
@allergydoc4kidz
Recognition of sequential epitopes associated with persistent CMA#AAAAI
@allergydoc4kidz
Little change in sIgE levels, but casein IgG4 levels increased in tolerant group #AAAAI
@allergydoc4kidz
Baked milk-tolerant 28x more likely to develop full tolerance than baked milk-reactive #AAAAI
@allergydoc4kidz
88 children, mostly school age, 74% baked milk tolerant, 60% developed full tolerance over course of study, only 9% in reactive group #AAAAI
@allergydoc4kidz
Published study of daily baked milk intake to assess impact on reactivity to unaltered milk #AAAAI
@allergydoc4kidz
Extensively heated/cooked milk alters conformational epitopes, may render non-allergic for up to 75% of CMA pts #AAAAI
@allergydoc4kidz
Up next, Jennifer Kim on potential mechanisms of tolerance induction with baked milk #AAAAI
@allergydoc4kidz
OIT with heated ovalbumin protected against oral but not parenteral challenge in murine model #AAAAI
@allergydoc4kidz
Soluble allergens (ALA) can induce sx orally, while insoluble allergens (casein) in murine milk model require parenteral exposure #AAAAI
@allergydoc4kidz
Induction of IL-1B and IL-6 through cutaneous exposure to PN#AAAAI
@allergydoc4kidz
Gut may be tolerogenic in all cases, sensitization may occur through other routes, such as the skin #AAAAI
@allergydoc4kidz
Th2 skewing in dendritic cells mediated by OX40L #AAAAI
@allergydoc4kidz
Local Ag-specific Treg cells induced by high-IL-10 expressing mucosal macrophages, disseminate into circulation #AAAAI
@allergydoc4kidz
GI dendritic cells are main mediator of default oral tolerance #AAAAI
@allergydoc4kidz
Soluble Ag's do not require Peyer's patches to cross the mucosal surface #AAAAI
@allergydoc4kidz
Challenge for intestinal mucosa is to differentiate non-cell Ag's (food, etc.) from pathogens #AAAAI
@allergydoc4kidz
First up, Cecilia Berin, epithelial and dendritic cell handling of food Ag's at the mucosal level #AAAAI
@allergydoc4kidz
Dissecting mechanisms of oral tolerance #AAAAI
READ FROM THE BOTTOM UP
------------------------------------------
3m @allergistmommy
Seems unlikely that drop method for SLIT will be FDA approved anytime soon. Tablets are more likely, but are less versatile. #AAAAI
5m @allergistmommy
Pts receiving SLIT able to tolerate 2500mg peanut, significantly more than placebo. #AAAAI
7m @allergistmommy
Recent study showed SLIT w/crude peanut extract (max dose 5000mcg/ml) had 11.5% reaction rate, predominantly oropharyngeal.#AAAAI
9m @allergistmommy
SLIT for food allergy. Is it safer than OIT? #AAAAI
10m @allergistmommy
Dose-dependent decrease in combined sx/Rx score for 6 and 12 Amb dose. #AAAAI
12m @allergistmommy
Ragweed tablet: evaluating 3 doses. 1.5, 6, and 12 Amb. #AAAAI
13m @allergistmommy
32% decrease in average combined sx/Rx score with grass pollen tablet (in adults). Mild adverse rxns (mainly oral pruritus). #AAAAI
17m @allergistmommy
SLIT reduced symptoms/medication scores, and increased IgG4.#AAAAI
18m @allergistmommy
Both adults and children in study. Most of them were multi sensitized. ~25% had asthma. #AAAAI
20m @allergistmommy
Tablet to Timothy grass studied over 2 years in a DBPC Randomized multicenter trial. Looked at combined symptom and Rx score. #AAAAI
24m @allergistmommy
Should SLIT be given pre- or co-seasonally? High or low dose?#AAAAI
26m @allergistmommy
Does SLIT work for multi-allergen treatment? Appears less effective. Are we saturating Langerhans cells, or are volumes too high? #AAAAI
27m @allergistmommy
FDA has not made clear what would be required for approval. Will likely be a higher standard than for Rx. Guess? P value < 0.005!#AAAAI
29m @allergistmommy
SLIT should not be considered a medication. It is more accurately described as a vaccine. #AAAAI
30m @allergistmommy
SLIT studies complicated by variability in pollen levels. #AAAAI
31m @allergistmommy
Why has it been so hard to get SLIT approved by the FDA? #AAAAI
32m @allergistmommy
Michael Blaiss presenting. Only recently do we have double-blind placebo controlled studies for SLIT. #AAAAI
34m @allergistmommy
Correction: timothy grass SLIT low dose was 15mcg (20,000 BAU), high dose 150mcg (200,000 BAU). #AAAAI
35m @allergistmommy
Caution that these results are preliminary, with very small "n". #AAAAI
37m @allergistmommy
The T helper cells aren't switching, per se. It appears to be a new clonal population of cells. #AAAAI
39m @allergistmommy
In high dose group, effector cells "switched" from Th2 to Th1. #AAAAI
43m @allergistmommy
IgG as a function of timothy grass SLIT dose: High-dose > low-dose > placebo. Sx: high < low < placebo. #AAAAI
47m @allergistmommy
Patients reached maintenance 1 month into therapy. Top dose administered daily for 12 months. Administered with metered dose pump. #AAAAI
49m @allergistmommy
Comparison of high (150mcg daily) and low dose (5mcg daily)Timothy grass SLIT. #AAAAI
50m @allergistmommy
Decreased T cell proliferation can be noted 2 months into SLIT therapy. #AAAAI
52m @allergistmommy
After SLIT, eosinophils are decreased in nasal, oral and bronchial mucosa. #AAAAI
53m @allergistmommy
IL10 (my favorite cytokine) and TGFbeta increase during SLIT.#AAAAI
54m @allergistmommy
Immature state of oral Langerhans cells appears critical for tolerance induction in SLIT. #AAAAI
55m @allergistmommy
SLIT induces/maintains desensitization. Shifts towards Th1, IgG4, possibly IgA. #AAAAI
57m @allergistmommy
Kari Nadeau discussing immunological mechanisms of SLIT. #AAAAI
58m @allergistmommy
State of sublingual immunotherapy in the U.S. #AAAAI
@DrAnneEllis
From Poster Session this morning: ketotifen may help with GI side effects of peanut desensitization #AAAAI
READ FROM BOTTOM UP
---------------------------
@MatthewBowdish • Although the number of allergists is small, we can have a far reach. Rapid desens is one niche we should own #AAAAI
25m @MatthewBowdish • Min req for rapid desens: 1-on-1 RN, CPR/ACLS, crash cart, epi at bedside, anesthesia/code team, allergist 3min from bedside #AAAAI
28m @MatthewBowdish • Is rapid desens a universal phenomenon? Yes Can all drugs be desensitized? Yes #AAAAI
29m @MatthewBowdish • Aspirin desens can often be performed in the outpatient setting these days, especially with the use of leukotriene inhibitors #AAAAI
36m @MatthewBowdish • Hypersensitivity reactions to mAbs: 105 desensitizations in 23 patients, from evaluation to treatment #AAAAI
bit.ly/AchKid
40m @MatthewBowdish • It's not always possible to desens everyone, but Mariana has had a very high rate of success (99%) #AAAAI
41m @MatthewBowdish • Safety of rapid desens - severe rxns in only 6% of cases at the Brigham #AAAAI
45m @MatthewBowdish • A protocol for risk stratification of patients with carboplatin-induced hypersensitivity reactions JACI 2012 #AAAAI
bit.ly/xtyrvV
47m @MatthewBowdish • Castells has a manuscript (in publication) for skin test dosing to chemotherapeutics #AAAAI
49m @MatthewBowdish • Pain is not a symptom of allergy but it is a symptom of angioedema - activation of kallikrein system? #AAAAI
51m @MatthewBowdish • Exclusion for rapid desens: Type III rxns, severe skin disease, stevens johnson, TEN, DRESS, ACE-induced angioedema #AAAAI
53m @MatthewBowdish • Allergist should always be on board for ordering rapid desens protocols, but other docs can supervise actual procedure #AAAAI
55m @MatthewBowdish • Rapid desens is high risk, performed on critically-ill pts and without done in pts without other viable treatment options #AAAAI
1h @MatthewBowdish • After desens, dose needs to be repeated every 2-2.5 half lives #AAAAI
1h @MatthewBowdish • Reaction to medications can be IgE or non-IgE mediated. Often, we don't understand the exact mechanism of reaction #AAAAI
h @MatthewBowdish • Next I'm attenidng Mariana Castells on Hypersensitivity to Drugs & Rapid Desensitization in the 21st Century #AAAAI
@mrathkopf: Annette Morris, MD - Bullying and Teasing in Children with Food Allergy ..... #AAAAI
@AllergieVoeding: "@allergistmommy: Children with food allergy suffer more anxiety around food than children with diabetes. #AAAAI"
@AllergieVoeding: "@DrSilge: prior study showed roughly 1 in 4 with food allergy were bullied specifically because of their food allergy. #AAAAI
@AllergieVoeding: "@DrSilge: Most bullying verbal, some physical by being threatened with food, one resulting in an allergic reaction. #AAAAI"
@mrathkopf: 1 in 3 middle and high school students are bullied. 17% increase since 2001. #AAAAI
@mrathkopf: Ann All Asthma Immun 2010;105:282-286-Bullying Among Pediatric Patients with Food Allergy-24% reported bullying due to food allergies #AAAAI
@mrathkopf: In the study presented, 34% of the 32 children reported being bullied #AAAAI
@mrathkopf: (bullying related to food allergy). Limitations - limited enrollment to date and fact that parents completed the questionnaire. #AAAAI
@AllergieVoeding: "@mrathkopf: 80-90% of egg allergic children will have atopic dermatitis. #AAAAI"
Quote from: CMdeux on March 02, 2012, 01:51:11 PM
This
Quote19 pts on OIT for 33-70 mths, off for 4 weeks, 11 remained tolerant to 5000mg
Is fairly disheartening, really.
It suggests pretty strongly that around half of PA patients probably cannot be truly "desensitized" unto tolerance. :-/ Makes me think (personally, after looking at all this science and research for over a decade now) that a LOT more basic research is needed in order to tease apart just who is and is not likely to benefit from this kind of intervention.
I mean, I suppose that it's better to need daily dosing forever than to be at risk of fatal anaphylaxis from an inadvertent exposure. But for female patients, that may not be so simple, either--
Quote
@allergydoc4kidz: Risk for unanticipated OIT rxn (not during buildup): fever, viral infection, exercise, menses #AAAAI
:( That is really discouraging.
Related to what I posted earlier:
http://www.medpagetoday.com/MeetingCoverage/AAAAIMeeting/31492 (http://www.medpagetoday.com/MeetingCoverage/AAAAIMeeting/31492)
Food Allergy May Make Kids Bullying TargetsQuoteBy John Gever, Senior Editor, MedPage Today
Published: March 05, 2012
Reviewed by Dori F. Zaleznik, MD; Associate Clinical Professor of Medicine, Harvard Medical School, Boston.
Action Points
These studies were published as abstracts and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal.
Explain that about a third of children in each of two survey studies reported being bullied because of their food allergies.
Note that in one of the surveys, in which parents and children were interviewed separately, nearly one-third of parents were unaware of the bullying, and for children who reported bullying episodes more than once a month, nearly two-thirds of those parents did not know about the bullying.
ORLANDO -- About one-third of children with food allergies are teased or harassed at school because of their condition, researchers said here.
The prevalence of bullying among children with food allergies was 29% in New York City and 34% in Jackson, Miss., according to reports from two separate surveys presented at the American Academy of Allergy, Asthma, and Immunology's (AAAAI) annual meeting.
Bullying tended to take place at school and was usually perpetrated by classmates and peers, but adults -- including teachers -- also were reported to have victimized children with food allergies.
And, in the New York study, parents often had no idea that their children had been bullied.
Children with any kind of minority status at school or in their neighborhoods are often singled out for verbal ridicule, social isolation, or even physical abuse.
A. Erika Morris, MD, of the University of Mississippi Medical Center in Jackson, Miss., noted that the constant dietary vigilance and the impacts on school attendance and performance can easily mark a child as different from peers and expose them to harassment.
She said her study was patterned after one published in 2010 by researchers in New York City led by Scott Sicherer, MD, of Mount Sinai Medical Center. It was the first to document clearly that food allergy is a stigmatizing factor, finding that 24% of food-allergic individuals (including adults and teens as well as young children) had experienced bullying related to their allergies.
The Mississippi study used the same questionnaire as in the earlier New York research, adapted to be more understandable to the lower socioeconomic-status population served in the Jackson clinic. Morris and colleagues administered it to 32 children or their parents (mostly the latter).
Some 85% of the children involved were younger than 12. Peanut and egg allergies were the most common.
Results indicated that 11 children, or 34%, had been bullied in some way -- harassed, taunted, teased, or physically abused -- because of their food allergies.
Morris said that, in line with earlier bullying studies, the bullying took place mainly at school and mainly by classmates. But, she said, in more than one instance teachers were perpetrators.
Most of the bullying was verbal, but parents or teen respondents reported that they were struck, pushed, or tripped.
There also were instances where bullies waved allergy-producing food items in the victims' faces or threw food at them. One respondent reported an allergic reaction occurring as a result.
Eight of the 11 children had been bullied for other reasons as well, including their size, race, age, or other medical conditions (including eczema in two cases).
Meanwhile, Sicherer and a different group of colleagues reported a new survey-based study at the AAAAI meeting following up on the 2010 effort.
Whereas the earlier study queried only teens and adults (mainly parents responding for their children), the new survey asked children eight to 17 years old and, separately, their parents about bullying the children had experienced.
The overall prevalence of allergy-related bullying was 28.8% among the 111 families included in the study. A slightly higher proportion (32.6%) of those in sixth through 10th grade reported having been bullied for their allergies.
Notably, Sicherer and colleagues found that, in 32% of allergy-related bullying cases reported by the children, their parents were unaware of it. And for 11 children who had reported being bullied more than once a month, 64% of parents did not know it.
"These results provide a strong argument that practitioners should specifically ask about bullying in this vulnerable population," the researchers said in their poster presentation.
Clinicians also should "provide anticipatory guidance about it even if it is not initially disclosed," they added.
Hello,
Any chance you have the slides from the Blaiss presentation to share?
Thanks
michael
Quote from: Macabre on March 03, 2012, 12:35:46 PM
READ FROM THE BOTTOM UP
------------------------------------------
3m @allergistmommy
Seems unlikely that drop method for SLIT will be FDA approved anytime soon. Tablets are more likely, but are less versatile. #AAAAI
5m @allergistmommy
Pts receiving SLIT able to tolerate 2500mg peanut, significantly more than placebo. #AAAAI
7m @allergistmommy
Recent study showed SLIT w/crude peanut extract (max dose 5000mcg/ml) had 11.5% reaction rate, predominantly oropharyngeal.#AAAAI
9m @allergistmommy
SLIT for food allergy. Is it safer than OIT? #AAAAI
10m @allergistmommy
Dose-dependent decrease in combined sx/Rx score for 6 and 12 Amb dose. #AAAAI
12m @allergistmommy
Ragweed tablet: evaluating 3 doses. 1.5, 6, and 12 Amb. #AAAAI
13m @allergistmommy
32% decrease in average combined sx/Rx score with grass pollen tablet (in adults). Mild adverse rxns (mainly oral pruritus). #AAAAI
17m @allergistmommy
SLIT reduced symptoms/medication scores, and increased IgG4.#AAAAI
18m @allergistmommy
Both adults and children in study. Most of them were multi sensitized. ~25% had asthma. #AAAAI
20m @allergistmommy
Tablet to Timothy grass studied over 2 years in a DBPC Randomized multicenter trial. Looked at combined symptom and Rx score. #AAAAI
24m @allergistmommy
Should SLIT be given pre- or co-seasonally? High or low dose?#AAAAI
26m @allergistmommy
Does SLIT work for multi-allergen treatment? Appears less effective. Are we saturating Langerhans cells, or are volumes too high? #AAAAI
27m @allergistmommy
FDA has not made clear what would be required for approval. Will likely be a higher standard than for Rx. Guess? P value < 0.005!#AAAAI
29m @allergistmommy
SLIT should not be considered a medication. It is more accurately described as a vaccine. #AAAAI
30m @allergistmommy
SLIT studies complicated by variability in pollen levels. #AAAAI
31m @allergistmommy
Why has it been so hard to get SLIT approved by the FDA? #AAAAI
32m @allergistmommy
Michael Blaiss presenting. Only recently do we have double-blind placebo controlled studies for SLIT. #AAAAI
34m @allergistmommy
Correction: timothy grass SLIT low dose was 15mcg (20,000 BAU), high dose 150mcg (200,000 BAU). #AAAAI
35m @allergistmommy
Caution that these results are preliminary, with very small "n". #AAAAI
37m @allergistmommy
The T helper cells aren't switching, per se. It appears to be a new clonal population of cells. #AAAAI
39m @allergistmommy
In high dose group, effector cells "switched" from Th2 to Th1. #AAAAI
43m @allergistmommy
IgG as a function of timothy grass SLIT dose: High-dose > low-dose > placebo. Sx: high < low < placebo. #AAAAI
47m @allergistmommy
Patients reached maintenance 1 month into therapy. Top dose administered daily for 12 months. Administered with metered dose pump. #AAAAI
49m @allergistmommy
Comparison of high (150mcg daily) and low dose (5mcg daily)Timothy grass SLIT. #AAAAI
50m @allergistmommy
Decreased T cell proliferation can be noted 2 months into SLIT therapy. #AAAAI
52m @allergistmommy
After SLIT, eosinophils are decreased in nasal, oral and bronchial mucosa. #AAAAI
53m @allergistmommy
IL10 (my favorite cytokine) and TGFbeta increase during SLIT.#AAAAI
54m @allergistmommy
Immature state of oral Langerhans cells appears critical for tolerance induction in SLIT. #AAAAI
55m @allergistmommy
SLIT induces/maintains desensitization. Shifts towards Th1, IgG4, possibly IgA. #AAAAI
57m @allergistmommy
Kari Nadeau discussing immunological mechanisms of SLIT. #AAAAI
58m @allergistmommy
State of sublingual immunotherapy in the U.S. #AAAAI
Michael, I'm guessing that if you want the slides to a particular presentation, the best tactic is to contact the presenting author directly.
Many authors/presenters are reluctant to share slide sets, but some will. It sometimes depends on how close a presentation is to being published, and in some cases whether or not that is the intention of the contributors.
In a meeting like this one, it's a mixed bag, since some clinicians aren't that interested in publications, and the research crowd is very committed to them.
https://academic.uthsc.edu/faculty/facepage.php?netID=mblaiss&personnel_id=121609 (https://academic.uthsc.edu/faculty/facepage.php?netID=mblaiss&personnel_id=121609)