study oral immunotherapy for desensitisation of peanut oil in children

[eragon]

http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(13)62301-6.pdf

[CMdeux]

HUGE step in the right direction, this study.

We did not exclude participants who had a
previous life-threatening reaction, tree-nut allergy, or a
history of severe asthma.

GOOD.   

Also worth noting that one of the 39 experimental group participants required epinephrine during the study.  Not unexpected, but this is an important feature that has (apparently) been pretty reproducible in OIT trials-- it is also a compelling reason why over-application of exclusion criteria isn't giving a lot of reassurance to those with the lowest thresholds or those with severe asthma/previous severe reaction history to low doses.

This one is different, because it gives a much clearer indication of what that rate of anaphylaxis might be in an unrestricted demographic that undergoes desensitization.

KWIM?

   

[spacecanada]

Agreed, CM.