Epinephrine Nasal Spray in Phase 1 of Trial

[Macabre]

https://snacksafely.com/2017/12/phase-i-trial-of-epinephrine-nasal-spray-for-anaphylaxis-begins/

INSYS Therapeutics announced Thursday that it has begun a proof-of-concept study of two formulations of epinephrine nasal spray for the treatment of anaphylaxis with the enrollment of the first patient.

This Phase I clinical trial is designed to establish whether intranasal administration of epinephrine is bioequivalent to the standard method of delivering the drug via intramuscular injection. . . . .

[PurpleCat]

Exciting!

[spacecanada]

I have to wonder how well a nasal spray would work with nasal symptoms being part of a reaction.  Think of a really snotty reaction; I don't think a spray could be effective then, or when you have congestion from other conditions such as viruses.  It will be interesting to see how the trial considers those factors. (They are spraying allergens in the nose and seeing how it affects the epinephrine.)

Sounds like an interesting experiment, for sure. 

[spacecanada]

My question has been answered... well, sort of.

https://www.prnewswire.com/news-releases/bryn-pharma-research-on-epinephrine-nasal-spray-presented-at-the-american-college-of-allergy-asthma-and-immunology-annual-meeting-300955162.html

Apparently congestion makes the nasal epinephrine more effective?  Someone please explain this to me better than the article above.  What about a gushing runny nose?  or sneezing? 

I'm not sure I would rely on it as a first measure, as I think IM may still be needed in some cases.  Still, more options are a good thing.  Great, even, if they work in a practical setting.