Eosinophilic Esophagitis(EE)

[LinksEtc]

Tweeted by @DrVes

"Swallowed topical corticosteroids reduce the risk for long-lasting bolus impactions in eosinophilic esophagitis"
http://onlinelibrary.wiley.com/doi/10.1111/all.12455/abstract?utm_content=buffer98edb&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

[LinksEtc]

Tweeted by @xFoodAllrgyhelp

"Study Finds Cause of Mysterious Food Allergy, Suggests New Treatment Strategy"
http://www.cincinnatichildrens.org/news/release/2014/eosinophilic-esophagitis-treatment/

"In a nutshell, we have used cutting edge genomic analysis of patient DNA as well as gene and protein analysis to explain why people develop EoE," Rothenberg explained. "This is a major breakthrough for this condition and gives us a new way to develop therapeutic strategies by modifying the expression of calpain14 and its activity.

[LinksEtc]

Tweeted by @FdAllergySleuth

High-Dose Fluticasone Effective Against Eosinophilic Esophagitis
NIH-Funded Study Also Uncovers Evidence of Steroid-Resistant Disease

http://www.niaid.nih.gov/news/newsreleases/2014/Pages/fluticasoneEoE.aspx

[LinksEtc]

"Eosinophilic Esophagitis - Scientific Excitement - Part 1 of 2"
http://foodallergysleuth.blogspot.com/2014/07/eosinophilic-esophagitis-scientific.html

The allergy world was abuzz this past week that a major research breakthrough for Eosinophilic Esophagitis (EoE) was published in Nature Genetics (1), spear-headed by Dr. Marc Rothenberg's lab at Cincinnati Children's Hospital. For anyone dealing with this devastating allergic disorder, the news was welcome, but what does it all mean?

--------------------------------------


"Eosinophilic Esophagitis - Scientific Excitement - Part 2 of 2"
http://foodallergysleuth.blogspot.com/2014/08/eosinophilic-esophagitis-scientific.html

Many factors contribute to the complex interplay of nature (DNA) and nurture (environmental effects on DNA expression) in both health and disease, and this is true for EoE and other allergic disorders.

CAPN14 is clearly one piece of the complex machinery that scientists are trying to reverse engineer.

[LinksEtc]

"Figuring out what was preventing Hunter Gallagher from swallowing would have taken a lot longer, if not for an ingenious device — a sponge on a string."

http://www.everydayhealth.com/news/eating-anything-made-him-sick/?xid=tw_dsg

But Hunter's doctors at the Mayo Clinic had another idea: a simple sponge on a string developed in the United Kingdom.

When a doctor pulls it back up, it scrapes the lining of the esophagus. It takes just five minutes and a pilot study found it was just as effective as an endoscopy.

[lilpig99]

Eosinophils and IL-9 promote mast cell accumulation in pediatric eosinophilic esophagitis

...
This study has a number of potentially important clinical implications. It demonstrates the eosinophil is an integral piece of the inflammatory puzzle in EoE and that by specifically removing the eosinophil using an anti-IL-5 antibody, there are secondary effects on other cells such as mast cells. In addition, this study shows, for the first time, that IL-9 is present and likely to be important in the pathogenesis of EoE. As such, IL-9 may provide a new therapeutic target in EoE.


The Journal of Allergy and Clinical Immunology (JACI) is the official scientific journal of the AAAAI and is the most cited journal in the field of allergy and clinical immunology

http://www.aaaai.org/global/latest-research-summaries/Current-JACI-Research/eosinophils-Il-9-promote-mast-cell.aspx

[LinksEtc]

"Scientists identify potential marker of EoE disease activity"
http://tinyurl.com/hxmqhqn

A potential marker of disease activity for a severe and often painful food allergic disease called eosinophilic esophagitis (EoE) has been discovered by researchers, possibly sparing children with EoE the discomfort and risk of endoscopic procedures to assess whether their disease is active.

Published May 16 in the Journal of Allergy and Clinical Immunology, researchers at the Cincinnati Center for Eosinophilic Disorders (CCED) at Cincinnati Children's Hospital Medical Center led the study.

----------------------



Tweeted by @AllergyEducator

"Food Allergy Testing in Eosinophilic Esophagitis"
http://tinyurl.com/l3ynyzn

[LinksEtc]

Tweeted by @Aller_MD

"CHOP joins CEGIR to advance treatment of eosinophilic disorders"
http://www.news-medical.net/news/20141009/CHOP-joins-CEGIR-to-advance-treatment-of-eosinophilic-disorders.aspx?utm_content=buffercf412&utm_medium=social&utm_source=twitter.com&utm_campaign=buffer

A five-year, $6.25 million NIH grant will establish the Consortium of Eosinophilic Gastrointestinal Disease Researchers, or CEGIR.

[LinksEtc]

I saw on twitter.

"Boy who couldn't eat now can stomach 12 foods"
http://www.wotimes.com/2015/01/boy-couldnt-eat-now-can-stomach-12-foods/

for me - always.read.fully - had to undo my rt.   

At first I thought this was just a nice EE article, but now I'm concerned about some of the info in it (although I am glad the boy is doing better).

the Hargers visited the Gerson Institute in San Diego

The alternative dietary Gerson Therapy was developed by Max Gerson (1881-1959), a German-born American physician who originally came up with the idea as a cure for his debilitating migraines. He further claimed it was a cure for cancer and most chronic, degenerative diseases.

----------------------------------


Reminded me of this    .....


Tweeted by @ScienceBasedMed

"A tale of two unnecessarily doomed aboriginal girls with leukemia"
January 20, 2015
http://scienceblogs.com/insolence/2015/01/20/a-tale-of-two-unnecessarily-doomed-aboriginal-girls-with-lymphoblastic-leukemia/

Brian Clement's clinic has nothing to do with Ongwehowe Onongwatri:yo (indigenous medicines) and everything to do with good, old-fashioned European-American quackery focused mainly on wheatgrass, raw vegan diet, and "detoxification."

there is still another aboriginal girl with lymphoblastic leukemia who has abandoned chemotherapy, with the blessing of her tribal chiefs and family, in favor of the quackery peddled by a Yankee in Florida. We don't know her name due to privacy concerns enforced during her court case but we do have an update about her condition to juxtapose with the death of Makayla Sault.

--------


Here's more ...


"The (Not-So-)Beautiful (Un)Truth about the Gerson protocol and cancer quackery"
http://www.sciencebasedmedicine.org/the-not-so-beautiful-untruth-about-the-gerson-therapy-and-cancer-quackery/

[lilpig99]

That's a lot to go through. But....yes....he scoped clean and that's so, so wonderful.