Anaphylaxis and Pre-Menarche

[akspearz]

My daughter is 12.5 and is currently experiencing
anaphylaxis with no known trigger. Symptoms occur about every 30 days. Allergist has been unable to pinpoint any correlation in diet
between episodes. We've had her allergy tested and no positive results. Diagonosis is idiopathic anaphylaxis. Currently taking a daily antihistimine
and have an Epi on hand. Have had to use Epi once and call the squad.  I have heard of allergies to progesterone or estrogen. Is there a way to test
a girl for this who hasn't started her period? Is this autoimmune progesterone dermatitis?

[GoingNuts]

Welcome!

I really don't have an answer to your question - the only person I knew with idiopathic anaphylaxis developed it in her 20's, and this was close to 40 years ago.  Very little was known about it at that time, other than alcohol seemed to play a role in her case - even just a sip or two.

Hopefully someone here will be able to steer you in the right direction.

[rebekahc]

Hi and welcome!  Like GoingNuts, I don't have any good answers for you.  I did find this article about progesterone hypersensitivity, the diagnosis, and successful treatment and desensitization in a 16 year old.  Hopefully it will at least give you a direction to look. 

https://www.annallergy.org/article/S1081-1206(18)31456-X/fulltext

My only other suggestion would be perhaps there's something food or environmental that your daughter might be allergic to and hormonal fluctuations cause her to be more sensitive and show clinical symptoms only during those fluctuations.  It's been proven that estrogen can make allergic symptoms worse, so I guess it could be a possibility.  I wonder if testing around 30 days from her last reaction would show any different results?  Of course, I'm guessing you're in prevent-anaphylaxis-mode at that point and testing wouldn't be possible with antihistamines in her system.

I'm sorry you and she are going through this!

[spacecanada]

I've never heard of this before, but it was in an article I read today: Catamenial Anaphylaxis is linked to the menstrual cycle.  I encourage you and your doctor to look it up; hopefully it's the answer you are looking for.