Nasal Epinephrine Study

[ajasfolks2]

Some of us have had nasal antihistamines prescribed as part of the ana treatment . . . (after epi given) . . . so thought this was interesting.

But of course the Epi would be quickly absorbed in those nasal tissues.


http://www.menafn.com/786edc58-4500-4ff6-b7d7-299111df21a4/Novel-Nasal-Epinephrine-Shows-Comparable-Absorption-to-EpiPenR-in-a-Feasibility-Study?src=main

[twinturbo]

whoah.

[Macabre]

I think compliance rate would increase. I wonder if the temp ranges would be greater.

Glad you saw this ajas. It's one of the things I was thinking we need to be aware of.

[CMdeux]

I can't be the only one recalling a reaction, though, in which this would be, er-- well, useless, to put it bluntly... given the volume and rate of SNOT production going on.

No?

Just me, then.   

[GoingNuts]

I can't be the only one recalling a reaction, though, in which this would be, er-- well, useless, to put it bluntly... given the volume and rate of SNOT production going on.

No?

Just me, then.   

Exactly what I was thinking, and wondering how the increased swelling and congestion might impact efficacy.

[ajasfolks2]

Heck, if could be nasal spray, then why not an ORAL SPRAY?  Talk about easy and convenient in many instances.


Would be quick absorption there as well?  Is intra nasal faster than intra oral?

(And I know those "intra" words should be one whole word each, but the damn autocorrect wanted to make the second one into intraMURAL.  GGA!!)

I can envision an epinephrine "kit" with both injectable and spray.

Sweet.

[spacecanada]

Very interesting!  Nasal spray may not work with snotty reactions, but mouth sprays may not work well with swollen tongues or mucous in the mouth either.  Could this also lead to sublingual spray?  Again, not so great with a swollen tongue. 

I don't think this would remove the need to carry injectable epinephrine, but it would certainly make it easier to treat reactions when excessive mucous or swollen tongue isn't present.   

[CMdeux]

Intranasal is a distinct route of administration-- absorption through the nasal mucosa is different than sublingual.  This is why people snort so many drugs rather than letting them dissolve under the tongue...    (No, really!)

If the idea is to produce a dramatic SPIKE in plasma concentration, that is.

[GoingNuts]

Intranasal is a distinct route of administration-- absorption through the nasal mucosa is different than sublingual.  This is why people snort so many drugs rather than letting them dissolve under the tongue...    (No, really!)

If the idea is to produce a dramatic SPIKE in plasma concentration, that is.

Ahem, I can think of another route of ingestion that might work as well...  Though I imagine it would not be a terribly attractive option to most folks. 

Carry on. 

[YouKnowWho]

Intranasal is a distinct route of administration-- absorption through the nasal mucosa is different than sublingual.  This is why people snort so many drugs rather than letting them dissolve under the tongue...    (No, really!)

If the idea is to produce a dramatic SPIKE in plasma concentration, that is.

Ahem, I can think of another route of ingestion that might work as well...  Though I imagine it would not be a terribly attractive option to most folks. 

Carry on. 

Pretty sure DS1 would volunteer for that over a shot.  DS2 likes needles    And during the GB blow-up, DH got quite a bit of practice with the other route.  He should be eligible for sainthood.

[twinturbo]

I can't see it replacing an injector but I'd certainly welcome carrying another back-up.

[CMdeux]

This could really be a great way of carrying a far more stable dose, too--

because it could really readily be packaged as a stable, N₂-cushioned ampoule with solid Epi-HCl in a measured dose, just waiting to be smashed and shaken into a measured volume of buffered saline.

High temperatures and lows would be nowhere near the level of concern.

[twinturbo]

Is it sad I get excited about novel methods to carry epinephrine and Benadryl?

[Janelle205]

Intranasal is a distinct route of administration-- absorption through the nasal mucosa is different than sublingual.  This is why people snort so many drugs rather than letting them dissolve under the tongue...    (No, really!)

If the idea is to produce a dramatic SPIKE in plasma concentration, that is.

Ahem, I can think of another route of ingestion that might work as well...  Though I imagine it would not be a terribly attractive option to most folks. 

Carry on. 

They do make an emergency seizure medication that is administered in this way.  Had one camper who had it when I was a director.

Imagine explaining that to your co-workers.

[CMdeux]

Yeah, I was chuckling to myself earlier that man, we only THINK that it's tough to get bystander action with an Epipen...